{"id":176,"date":"2025-02-16T17:12:52","date_gmt":"2025-02-16T16:12:52","guid":{"rendered":"https:\/\/bulletin-micronutrition.com\/?p=176"},"modified":"2025-02-21T13:47:46","modified_gmt":"2025-02-21T12:47:46","slug":"article-2","status":"publish","type":"post","link":"https:\/\/bulletin-micronutrition.com\/?p=176","title":{"rendered":"Int\u00e9r\u00eat de l\u2019approche micro-nutritionnelle dans l\u2019accompagnement des maladies auto-immunes comme la maladie de Crohn"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"<p>La maladie de Crohn est une maladie inflammatoire chronique de l\u2019intestin (MICI), li\u00e9e \u00e0 une hyperactivit\u00e9 du syst\u00e8me immunitaire. Bien que son \u00e9tiologie ne soit pas totalement comprise, il appara\u00eet qu\u2019un microbiote intestinal dysbiotique est associ\u00e9 au d\u00e9veloppement et \u00e0 la persistance de la maladie, cette dysbiose \u00e9tant associ\u00e9e \u00e0 une hyperperm\u00e9abilit\u00e9 intestinale. L\u2019hyperperm\u00e9abilit\u00e9 serait plut\u00f4t la cause de l\u2019auto-immunit\u00e9 que l\u2019inverse.<br \/>\nCompte-tenu du fait que certains compos\u00e9s alimentaires peuvent influer sur le niveau de perm\u00e9abilit\u00e9 des jonctions serr\u00e9es, influencer le microbiote intestinal ou la fonction immunitaire de la muqueuse, l\u2019approche micro-nutritionnelle ouvre une voie int\u00e9ressante pour la stabilisation des maladies auto-immunes. Acides amin\u00e9s, acides gras om\u00e9ga-3, vitamine D (bien que donn\u00e9es contradictoires), antioxydants, zinc, fibres pr\u00e9biotiques offrent un certain potentiel, que ce soit pour am\u00e9liorer la fonction barri\u00e8re de l\u2019intestin, moduler l\u2019inflammation ou la fonction immunitaire, ou la composition et la fonction du microbiote intestinal.<br \/>\nEtant donn\u00e9 le r\u00f4le central de la dysbiose dans la maladie de Crohn, on peut pr\u00e9sumer que l&rsquo;introduction de bact\u00e9ries probiotiques pourrait potentiellement permettre d\u2019\u00e9voluer vers un microbiote plus sain. Si la suppl\u00e9mentation en certains probiotiques apporte des b\u00e9n\u00e9fices \u00e0 court terme, les \u00e9tudes montrent que les souches peinent souvent \u00e0 s\u2019implanter durablement.<br \/>\n<br \/>\nCrohn\u2019s disease is a chronic inflammatory bowel disease (IBD), linked to a hyperactivity of immune system. Although its etiology is not fully understood, it appears that a dysbiotic intestinal microbiota is associated with the development and maintenance of the disease. This dysbiosis is associated with a leaky gut, which would rather be the cause of autoimmunity than the opposite.<br \/>\nCertain food compounds can influence the level of permeability of tight junctions, the intestinal microbiota, or the immune function of the mucosa. So, micro-nutritional approach offers a complementary route for the stabilization of autoimmune diseases. Amino acids, omega-3 fatty acids, vitamin D (although conflicting data), antioxidants, zinc, prebiotic fiber\u2026 present some potential, whether to improve gut barrier function, modulate inflammation, immune function, or the composition and function of gut microbiota.<br \/>\nGiven the central role of dysbiosis in Crohn&rsquo;s disease, it can be assumed that the introduction of probiotic bacteria could potentially lead to a healthier microbiota. While supplementation with specific probiotics provides short-term benefits, studies show that long-term colonization is rare.<\/p>\n","protected":false},"author":1,"featured_media":9,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-176","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classe"],"_links":{"self":[{"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=\/wp\/v2\/posts\/176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=176"}],"version-history":[{"count":9,"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=\/wp\/v2\/posts\/176\/revisions"}],"predecessor-version":[{"id":543,"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=\/wp\/v2\/posts\/176\/revisions\/543"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=\/wp\/v2\/media\/9"}],"wp:attachment":[{"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=176"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bulletin-micronutrition.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}